The effects of crude alkaloid extract of Matricaria chamomilla L. on convulsions induced by pentylenetetrazole in chicks

The present research was designed to evaluate the protective effect of crude alkaloid extract Matricaria chamomilla L. (MC) against pentylenetetrazole (PTZ) induced convulsions in chicks. A total seventy-two chicks were randomly divided into six groups each one consisting 12 first group considered be a negative that received subcutaneous injection normal saline, second (positive control) PTZ (90 mg/kg), and third sodium valproate (200 mg/kg) orally for days. other (fourth, fifth sixth) treated with single intraperitoneal alkaloids MC (20, 40, 80 respectively. After 30 minutes treatment, (third observed convulsion signs next minutes. At end experiment, various biochemical parameters assessed including, brain gamma-aminobutyric acid (GABA) glutamate, serum catalase (CAT), glutathione reductase (GR), malondialdehyde (MDA), 8-isoprostane, some electrolytes (potassium K+, Na+, chloride Cl-, ionized calcium iCa2+, TCa2+), pH, glucose levels serum. results indicated at higher dose (80 showed significant increase CAT significantly decreased an Na+ ions concentration It concluded pretreatment offers anticonvulsant activity by reducing mortality rate PTZ, as well it plays important role inhibiting oxidative stress.